[EN] The dissertation is dedicated to Wilson’s disease (WD) – a rare inherited autosomal recessive disease, related to a disorder of copper metabolism. Its aim is to optimize the diagnostic and therapeutic approach to this ...

[EN] Up to date there are no sufficient data for osteoprotegerin (OPG) concentrations in newly diagnosed type 2 diabetic patients. Two screening programs for glycemic abnormalities among risk groups were performed. This ...

[EN] The study included 189 patients with colorectal cancer (CRC), of them 98 Bulgarian and 81 German. Data regarding familial history for cancer, tumor location along the colon, histology and stage according to TNM ...

[EN] This PhD thesis focuses on the autoimmune liver diseases, namely, autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis and their overlapping syndromes. Comprehensive characterization ...

[EN] The dissertation deals with the rectal carcinoma which is a disease of great social impact. The abilities of the different methods for diagnosis and preoperative staging are analysed. The epidemiology, cancerogenesis, ...

[EN] The study investigates the thrombocytopoietic activity of plasma in patients with chronic renal failure (CRF). Thrombocytopoietic activity is tested using two methods - by determining the incorporation of 75 Se-M into ...

[EN] The study presents immunophenotyping as an advanced and precise method used in modern immunology by testing series of immunological parameters. It contributes significantly to comparing and monitoring changes in immune ...

[EN] Approximately half of patients with terminal kidney failure suffer from one or another form of glomerulonephritis. To a significant extent, glomerular diseases result from primary or secondary glomerular involvement ...

[EN] Thyroid gland diseases, especially autoimmune and tumour diseases, hold a basic place in clinician's everyday practice. Unresolved issues related to the course, successful treatment, and long term prognosis in patients ...

[EN] Proteinuria is an important marker for the diagnosis and monitoring of the activity of chronic glomerulopathies. It is associated with increased cardiovascular risk and the risk of progressive deterioration of the ...