Катедра по физиология и патофизиология / Department of Physiology and Pathophysiology
Recent Submissions
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Experimental Study on the Effects of Melatonin Supplementation on Obesity-Induced Endothelial Dysfunction // Изследване на ендотелната дисфункция при експериментален модел на затлъстяване и суплементация с мелатонин
(Medical University of Varna, 2022)Obesity is a medical and social problem due to associated comorbidities. It is believed that endothelial dysfunction (ED) links the latter with obesity and triggers the development of cardiovascular disorders (CVD). ... -
Influence of Subchronically Applied Ligands on the Cannabinoid Receptors on Learning and Memory Processes in Olfactory Bulbectomized Rats // Влияние на субхронично въвеждани лиганди на канабиноидните рецептори върху обучителните и паметови процеси на плъхове с олфакторна булбектомия
(Medical University of Varna, 2022)The main task of the present study is, by using various ways of applications: i.c.v. and intragastric, in the conditions of the subchronic experiment (7 and 14 days), to evaluate the effects of ligands on cannabinoid ... -
Role of the Endocannabinoid System in Behavioral Reactions in a Depressive-Like Condition // Роля на ендоканабиноидната система в поведенчески реакции при депресивно-подобно състояние
(2018)Endocannabinoid system (ESS) is a mediator system with lipid mediators. Its main components are the cannabinoid receptors (CB1R and CB2R) and the endocannabinoids – N arachidonoylethanolamine (anadamide) and 2-arachidono ... -
Pathophysiological Aspects of Active Tubulointerstitial Bacterial Nephritis by Clinical and Laboratory Data /// Патофизиологични аспекти на активния тубулоинтерстициален бактериален нефрит по клинично-лабораторни данни
(2018)Bacterial infections in kidneys and urinary tract infections (UTIs) often occur clinically with scarce symptoms and minor complaints, therefore they are difficult to diagnose and relatively late or are subject to hyperdiagnosis. ... -
Experimental Evidences for Hypocoagulability Caused by Thymic Peptides Thymulin, Thymosin alpha 1 and Thymosin beta 4 /// Експериментални доказателства за хипокоагулабилитет, породен от тимусните пептиди тимулин, тимозин-алфа 1 и тимозин-бета 4
(2017)Thymus is the main immune organ of the organism. It is also a gland and an intrinsic component of the endocrine system. However, despite the identification of several thymic “hormones,” the model of endocrine cell-to-cell ... -
Brain Functional Asymmetry: Handedness and Gender /// Функционална мозъчна асиметрия: ръкост и пол
(2000)[EN] Brain functional asymmetry is a particularly interesting and topical issue in modern natural science, biology and medicine. Standard models of asymmetry are based on the dichotomous division of functional competence ... -
Study of Potential Mechanisms of Gastric Mucosal Injury and the Effect of Melatonin in Model of Thermal Skin Trauma // Проучване на възможни механизми за увреждане на стомашната лигавица и влиянието на мелатонина при модел на термична травма
(2016)The dissertation is a complex and systemic pathophysiological and biochemical study of potential mechanisms for gastric mucosal injury induced through an experimental model of thermal trauma. Examination of the degree of ... -
Mechanism of Hepatocyte Survival in Experimental Model of Non-Alcoholic Fatty Liver and Antioxidants Intake // Механизъм на хепатоцитно оцеляване при експериментален модел на неалкохолен мастен черен дроб и прием на антиоксиданти
(2015)Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease which is associated with the increasing of obesity, diabetes type 2, cardiometabolic diseases and metabolic syndrome. NAFLD includes a ... -
Selenium and Functional State of the Vessel Wall under Normo- and Hypertension - Experimental Research // Селен и функционално състояние на съдовата стена при нормо- и хипертензия - експериментални проучвания
(2012)[EN] The aim of this study is to investigate the effects of the different selenium (Se) intake on oxidative status and their impact on the lipid profile and the state of the vessel wall in normotensive Wistar-Kyoto rats ... -
Thyroid hormonal axis as a significant regulator of haemostasis // Тироидната хормонална ос - значим регулатор на хемостазата
(2012)[EN] This dissertation deals with a current and significant problem in contemporary medical theory and practice. The effect of thyroid axis hormones, i.e. TRH (Thyrotropin releasing hormone), TSH (Thyroid stimulating ... -
Brain asymmetry and left-handedness: theories of origin and associated psychophysiological phenomena // Мозъчна асиметрия и леворъкост: теории за произхода и свързани психофизиологични феномен
(2013)[EN] The study presents a comprehensive review on theories regarding the origin of left-handedness. A longitudinal study of populational proportions of handedness provides data supporting the genetic models of Annett (1972; ... -
Investigation of the regulatory effects of vitamin D analogues on calcium-phosphorus metabolism at renal function replacement // Проучване на регулаторните ефекти на аналози на витамин D върху калциево-фосфорната обмяна при заместване на бъбречната функция
(2014)The calcium-phosphorus metabolism is an important element of the overall mechanism supporting the homeostasis and is also a significant factor in the integrity and functional capability of the locomotory system. Impairments ... -
Study On Some Possible Liver Damage Mechanisms Related To Oxidative Stress In Experimental Thermal Trauma Conditions And Melatonin Hepatoprotection Role// Проучване на някои възможни механизми за увреждане на черния дроб, свързани с оксидативния стрес в условията на експериментална термична травма и ролята на мелатонина в хепатопротекцията
(2014)[EN] This is the first of its kind comprehensive study focused on the potential pathophysiological mechanisms of liver damage after thermal injury associated with the development of oxidative stress. Test results are ... -
Melatonin-initiated Effects on The Triggering Mechanism of Hemostasis in Rats // Мелатонин-инициирани ефекти върху пусковия механизъм на хемостазата у плъхове
(2015)[EN] Melatonin is a hormone with a broad spectrum of biological activity, but its role in the processes of hemostasis has been insufficiently explored. The purpose of this disseration is to study melatonin's influence on ... -
Experimental Proof of The Regulatory Effects of Melatonin on The Coagulant and Anticoagulant Systems in Rats// Експериментални доказателства за регулаторните ефекти на мелатонина върху коагулационната и антикоагулационна системи у плъхове
(2015)[EN] In the following work the influence of melatonin over 20 indicators of the coagulant and anticoagulant systems in rats is being investigated, given that data regarding this hormone's effects on hemostasis is scarce ...
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