3. Фармация / Pharmacy
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Synthesis, Characterization and Toxicity Study of Bexarotene Esters // Синтез, охарактеризиране и изследване на токсичността на естери на Бексаротен
(Medical University of Varna, 2023)Retinoids are used in the treatment of skin diseases and some types of cancer. Their role in vision, embryonic development, regulation of cell proliferation and differentiation, homeostasis and various aspects of metabolism ... -
New Strategies for the Qualitative and Quantitative Analysis of Nitrofural and Its New Derivatives // Нови стратегии за качествения и количествен анализ на Nitrofural и неговите нови производни
(Medical University of Varna, 2022)Over the last few decades, polymorphism has become increasingly important in global pharmaceutical production. Today, in pharmaceutical practice, the concept of polymorphism is the knowledge that polymorphism is the most ... -
Synthesis, Structure and Properties of New Iodine Derivatives of Natural Aromatic Acids // Синтез, структура и свойства на нови йодопроизводни на природни ароматни киселини
(Medical University of Varna, 2022)Iodination reactions of organic substrates are one of the most significant chemical transformations in pharmaceutical synthesis. No less important are the reactions that use the already obtained iodine-substituted compounds ... -
Isolation and Analysis of Methylxanthine Fraction, Catechin Fraction and Total Bancha Green Tea Extract and Study of Their Influence on the Pharmacokinetics of Sildenafil in Rats // Изолиране и анализ на метилксантинова фракция, катехинова фракция и цялостен екстракт от зелен чай Банча и проучване на влиянието им върху фармакокинетиката на силденафил при плъхове
(Medical University of Varna, 2022)Green tea is known for a number of beneficial effects such as antioxidant, anti-inflammatory and antimicrobial activity, antitumor effect and others. Tea leaves contain a wide variety of biologically active substances ... -
Quantitative and Qualitative Characteristics of Autologous Platelet Concentrates and the Biological Significance of Their Proteins // Количествени и качествени характеристики на автоложни тромбоцитни концентрати и биологичното значение на протеините в тях
(Medical University of Varna, 2021)The use of platelet-rich plasma (PRP) is defined as a revolutionary, alternative method in medicine. The procedure is a biological therapy based on observations of the role of platelets in the natural process of repairing ... -
Characteristics of Acute Medicinal Poisoning in Varna District over a 30-Year Period // Характеристика на острите медикаментозни отравяния във Варненска област за 30-годишен период
(Medical University of Varna, 2021)Poisoning is a significant public health problem. According to WHO data, in 2016, more than 1,206,000 people died due to accidental poisoning. There are significant differences in patterns of poisoning between different ... -
Ethnobotanical Study of the Medicinal Plants in the Region of the North Black Sea Coast // Етноботаническо проучване на лечебните растения в района на северночерноморско крайбрежие
(Medical University of Varna, 2021)The ethnobotanical study of medicinal plants in the region of the North Black Sea coast describes the knowledge of the locals about the application of medicinal plants in: human and veterinary medicine, for cosmetic and ... -
Investigation and Screening Methods for Early Diagnosis of Patients with Gastrointestinal Disorders Due to Mushroom Consumption // Проучвания и скринингови методи за ранна диагностика на пациенти с гастроинтестинални разстройства вследствие на консумация на гъби
(Medical University of Varna, 2021)We analysed the intoxications with wild mushrooms among the population in the Northern Bulgarian Black Sea coast between 1991 and 2015. Two easily feasible methods for their diagnosis, such as Meixner’s test and ELISA, ... -
Research on the Correlation between the Optical Properties and Antioxidant Effect of Extracts and Juices of Traditional Medicinal Plants Using the Methods of Applied Photonics // Проучване на връзката оптични свойства – антиоксидантен ефект на екстракти и сокове от традиционни лечебни растения чрез методите на приложната фотоника
(Medical University of Varna, 2021)This thesis aims to apply the methods of photonics as qualitative and semi-quantitative tools for studying the relationship between optical properties and antioxidant effect of extracts and juices of medicinal plants in ... -
Pharmacological Studies of Steroid Hormones, Natural Products and Newly Synthesized 2h-Substituted Hydrasid-Hydrasones in Experimental Models of Epilepsy, Pain and Osteoporosis // Фармакологични проучвания на стероидни хормони, природни продукти и новосинтезирани 2H-субституирани хидразид-хидразони в експериментални модели на епилепсия, болка и остеопороза
(Medical University of Varna, 2020)Epilepsy is one of the most severe neurological conditions. Based on a number of clinical and laboratory studies it is known that steroid hormones have a significant role in epileptogenesis. One of the purposes of this ... -
Some Deontological Considerations Related to Features of Communication with Patients with Acute Intoxication // Някои деонтологични проблеми, свързани с особеностите на комуникацията с пациенти с остри отравяния
(Medical University of Varna, 2021)Deontological problems are common in clinical toxicology. This is a current socially-significant topic because of the large number of acute poisonings. The aim of the dissertation is to examine the deontological considerations ... -
Study of the Effects of Intravenous Lipid Infusion in Acute Intoxications with Some Xenobiotics // Проучване ефектите на интравенозна липидна инфузия при остри интоксикации с някои ксенобиотици
(Medical University of Varna, 2021)We investigate the protective role of intravenous infusion of fat emulsions as an antidote in acute intoxications with some lipophilic xenobiotics, exhibiting neurotoxic effects - drugs and organophosphorus pesticides ... -
New aspects in the liquid chromatographic analysis of Capecitabine in samples of biological and non-biological origin // Нови аспекти в течнохроматографския анализ на Capecitabine в проби от биологичен и небиологичен произход
(Medical University of Varna, 2021)The treatment of malignancies is a serious challenge for the modern healthcare system. Evidence of this is the drastic increase in morbidity and mortality due to cancer globally (by 44% and 26%, respectively). On the other ... -
Synthesis and Characterization of Substituted Imidazole Derivatives with Potential Biological Effect // Синтез и охарактеризиране на заместени производни на имидазола с потенциален биологичен ефект
(Medical University of Varna, 2021)The antimicrobial agents were discovered more than 100 years ago. However, the struggle with bacterial agents continues at present. The development process of searching for new antimicrobial drugs include global research ... -
European Practices and Standards for Digital Forms of Continuing Education of Medical Professionals in The Field of Medicines Policy // Европейски практики и стандарти за дигитални форми на продължаващо обучение на медицински специалисти в сферата на лекарствената политика
(Medical University of Varna, 2021)Continuing education as a key element of lifelong learning becomes increasingly important in the modern globalized world as access to information is facilitated, and constantly upgraded digital methods of education strengthen ... -
New Aspects in the Analysis of Diltiazem-Loaded Polymeric Drug Delivery Systems // Нови аспекти в анализа на Diltiazem базирани полимерни лекарство-доставни системи
(Medical University of Varna, 2020)We focus on the analysis of contemporary drug delivery systems. The main object of the study is the drug Diltiazem (blocker of the L-type Ca2+ channels) and the newly synthesized Diltiazem-loaded Eudragit RS 100-based drug ... -
The Pharmacist's Role in Consulting Patients with Joint Diseases // Роля на магистър-фармацевта при консултиране на болни със ставни заболявания
(Medical University of Varna, 2020)The study examines the role of the master pharmacist in improving the physical condition of chronically ill patients with joint disease (osteoarthritis) through the application of individualized pharmaceutical care. Analyzing ... -
Screening and Functional Analysis of New Anti-Complement Autoantibodies in the Course of Systemic Lupus Erythematosus // Скрининг и функционален анализ на нови анти-комплементни автоантитела в хода на системен лупус еритематодес
(Medical University of Varna, 2020)The role of autoimmunity and the loss of immune tolerance to own proteins have a significant place in the current ideas about the aetiology and pathogenesis of systemic lupus erythematosus (SLE). The disease is characterized ... -
Research on the Molecular Mechanisms of Sulfur-Containing Mineral Waters from the Varna Basin on Human Metabolism in Regards to Their Usage as a Drinking Remedy // Проучване на молекулните механизми на въздействие на сяросъдържащите минерални води от Варненския басейн върху човешкия метаболизъм с оглед използването им като лечебно питейно средство
(Medical University of Varna, 2020)The purpose of the present research was to study the effects of Varna mineral waters on human metabolism with respect to their potential usage as a drinking remedy. An 8 weeks human intervention study with mineral water ... -
Optical characteristics of wines: development of an express method for wines’ comparative identification and its application in practice // Изследване на оптичните характеристики на вина с цел разработване на експресен метод за тяхното сравнително идентифициране и приложението му в практиката
(Medical University of Varna, 2020)This study aims to investigate and determine the optical characteristics of wines by using the methods and means of applied photonics, to study their antioxidant properties as well as to establish the correlations between ...
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